Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50132538
Substrate
n/a
Meas. Tech.
ChEBML_1121
Ki
56±n/a nM
Citation
 López-Rodríguez, ML; Benhamú, B; Morcillo, MJ; Tejada, I; Avila, D; Marco, I; Schiapparelli, L; Frechilla, D; Del Río, J Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands. Bioorg Med Chem Lett 13:3177-80 (2003) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50132538
Synonyms:
2-[4-(2-Propoxy-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole-4-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide | CHEMBL110549
Type:
Small organic molecule
Emp. Form.:
C29H38N6O2
Mol. Mass.:
502.651
SMILES:
CCCOc1ccccc1N1CCN(Cc2nc3cccc(C(=O)NC4CN5CCC4CC5)c3[nH]2)CC1 |THB:24:25:31.32:29.28,(10.11,-.12,;10.88,-1.45,;10.1,-2.78,;10.85,-4.13,;10.08,-5.44,;10.83,-6.79,;10.05,-8.12,;8.51,-8.1,;7.75,-6.76,;8.54,-5.44,;7.79,-4.1,;7.6,-2.78,;8.5,-1.29,;7.31,-.31,;6.54,1.03,;5,1.03,;4.08,-.23,;2.61,.25,;1.27,-.52,;-.06,.25,;-.06,1.8,;1.27,2.57,;1.27,4.12,;2.6,4.89,;-.07,4.87,;-1.41,4.1,;-1.32,2.67,;-2.6,3.51,;-4.22,3.07,;-4.21,4.48,;-2.65,4.91,;-2.35,6.52,;-2.07,5.36,;2.61,1.8,;4.08,2.28,;7.51,-1.54,;6.6,-3.13,)|
Structure:
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