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Target
Cruzipain
Ligand
BDBM50133617
Substrate
n/a
Meas. Tech.
ChEMBL_210992 (CHEMBL812106)
IC50
90000±n/a nM
Citation
 Chiyanzu, I; Hansell, E; Gut, J; Rosenthal, PJ; McKerrow, JH; Chibale, K Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett 13:3527-30 (2003) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50133617
Synonyms:
1-Benzyl-5-iodo-1H-indole-2,3-dione | 1-benzyl-5-iodoindoline-2,3-dione | CHEMBL118596 | acs.jmedchem.1c00409_ST.706
Type:
Small organic molecule
Emp. Form.:
C15H10INO2
Mol. Mass.:
363.1499
SMILES:
Ic1ccc2N(Cc3ccccc3)C(=O)C(=O)c2c1
Structure:
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