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TargetSodium-dependent noradrenaline transporter
LigandBDBM50136679
Substrate/Competitorn/a
Meas. Tech.ChEBML_142612
Ki 110±n/a nM
Citation Bymaster, FPBeedle, EEFindlay, JGallagher, PTKrushinski, JHMitchell, SRobertson, DWThompson, DCWallace, LWong, DT Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett13:4477-80 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Monoamine transporter
Synonyms:NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SLC6A2 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:P23975
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50136679
NameBDBM50136679
Synonyms:CHEMBL141741 | Methyl-[3-(naphthalen-1-yloxy)-3-o-tolyl-propyl]-amine
TypeSmall organic molecule
Emp. Form.C21H23NO
Mol. Mass.305.4134
SMILESCNCCC(Oc1cccc2ccccc12)c1ccccc1C
Structure
n/a