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TargetCathepsin K
LigandBDBM50138854
Substrate/Competitorn/a
Meas. Tech.ChEMBL_45540
IC50 15±n/a nM
Citation Tavares, FXBoncek, VDeaton, DNHassell, AMLong, STMiller, ABPayne, AAMiller, LRShewchuk, LMWells-Knecht, KWillard, DHWright, LLZhou, HQ Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k. J Med Chem47:588-99 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50138854
NameBDBM50138854
Synonyms:CHEMBL345356 | [(S)-1-(2-Phenyl-2H-pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester
TypeSmall organic molecule
Emp. Form.C24H34N4O4
Mol. Mass.442.5512
SMILESCCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1ccnn1-c1ccccc1
Structure
n/a