Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50139383
Substrate
n/a
Meas. Tech.
ChEBML_83647
Ki
2.2±n/a nM
Citation
 Cowart, M; Pratt, JK; Stewart, AO; Bennani, YL; Esbenshade, TA; Hancock, AA A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans. Bioorg Med Chem Lett 14:689-93 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50139383
Synonyms:
(4-{2-[2-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-phenyl)-morpholin-4-yl-methanone | CHEMBL159617
Type:
Small organic molecule
Emp. Form.:
C27H32N2O3
Mol. Mass.:
432.5546
SMILES:
C[C@@H]1CC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: