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Target
Histamine H3 receptor
Ligand
BDBM50139382
Substrate
n/a
Meas. Tech.
ChEMBL_83797 (CHEMBL692573)
Ki
1.2±n/a nM
Citation
 Cowart, M; Pratt, JK; Stewart, AO; Bennani, YL; Esbenshade, TA; Hancock, AA A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans. Bioorg Med Chem Lett 14:689-93 (2004) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50139382
Synonyms:
(4-{2-[2-((2R,6S)-2,6-Dimethyl-piperidin-1-yl)-ethyl]-benzofuran-5-yl}-phenyl)-morpholin-4-yl-methanone | CHEMBL159519
Type:
Small organic molecule
Emp. Form.:
C28H34N2O3
Mol. Mass.:
446.5812
SMILES:
C[C@H]1CCC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C(=O)N1CCOCC1
Structure:
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