Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50138842
Substrate
n/a
Meas. Tech.
ChEBML_48340
IC50
20±n/a nM
Citation
Catalano, JG; Deaton, DN; Long, ST; McFadyen, RB; Miller, LR; Payne, JA; Wells-Knecht, KJ; Wright, LL Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 14:719-22 (2004) [PubMed] Article
More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_RAT | Ctsk
Type:
PROTEIN
Mol. Mass.:
36798.82
Organism:
Rattus norvegicus
Description:
ChEMBL_633322
Residue:
329
Sequence:
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
Inhibitor
Name:
BDBM50138842
Synonyms:
2,4-dimethylpentan-3-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | CHEMBL84691 | [(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester | [(S)-1-(4-Bromo-1H-pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C23H36N2O4
Mol. Mass.:
404.5429
SMILES:
CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1