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Target
Dihydrofolate reductase
Ligand
BDBM18510
Substrate
n/a
Meas. Tech.
ChEMBL_54217 (CHEMBL668096)
IC50
5000±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Sibley, CH; Inderlied, CB; Queener, SF New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. J Med Chem 47:1475-86 (2004) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM18510
Synonyms:
5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenoxy}pentanoic acid | CHEMBL37520 | Diaminopyrimidine, 22
Type:
Small organic molecule
Emp. Form.:
C17H22N4O4
Mol. Mass.:
346.381
SMILES:
COc1ccc(OCCCCC(O)=O)cc1Cc1cnc(N)nc1N
Structure:
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