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Target
C-C chemokine receptor type 5
Ligand
BDBM50143762
Substrate
n/a
Meas. Tech.
ChEMBL_39506 (CHEMBL654035)
IC50
0.8±n/a nM
Citation
 Thoma, G; Nuninger, F; Schaefer, M; Akyel, KG; Albert, R; Beerli, C; Bruns, C; Francotte, E; Luyten, M; MacKenzie, D; Oberer, L; Streiff, MB; Wagner, T; Walter, H; Weckbecker, G; Zerwes, HG Orally bioavailable competitive CCR5 antagonists. J Med Chem 47:1939-55 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50143762
Synonyms:
(2,6-Dimethyl-phenyl)-[4'-methyl-4-(4-trifluoromethyl-phenylamino)-[1,4']bipiperidinyl-1'-yl]-methanone | CHEMBL58897
Type:
Small organic molecule
Emp. Form.:
C27H34F3N3O
Mol. Mass.:
473.5736
SMILES:
Cc1cccc(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)Nc1ccc(cc1)C(F)(F)F
Structure:
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