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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50145265
Substrate
n/a
Meas. Tech.
ChEBML_144155
IC50
23±n/a nM
Citation
 Rueeger, H; Gerspacher, M; Buehlmayer, P; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Whitebread, S; Nuesslein-Hildesheim, B; Nick, H; Cricione, L Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 14:2451-7 (2004) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50145265
Synonyms:
CHEMBL81000 | N-{4-[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-cyclohexylmethyl}-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C17H22FN3O2S2
Mol. Mass.:
383.504
SMILES:
CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(cs1)-c1ccc(F)cc1 |wU:9.12,wD:6.5,(11.02,4.84,;9.92,3.75,;11.37,3.19,;9.68,5.26,;8.73,2.77,;7.28,3.3,;6.09,2.33,;4.66,2.87,;3.46,1.9,;3.72,.39,;5.16,-.16,;6.35,.81,;2.54,-.59,;1.1,-.05,;-.19,-.91,;-1.39,.06,;-.86,1.49,;.68,1.42,;-2.87,-.36,;-3.96,.72,;-5.45,.3,;-5.85,-1.19,;-7.32,-1.59,;-4.75,-2.27,;-3.26,-1.87,)|
Structure:
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