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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50147392
Substrate
n/a
Meas. Tech.
ChEBML_72489
IC50
9800.0±n/a nM
Citation
 Song, YL; Roller, PP; Long, YQ Development of l-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity. Bioorg Med Chem Lett 14:3205-8 (2004) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50147392
Synonyms:
(R)-21-Carbamoyl-33-carbamoylmethyl-15-((S)-3-carboxy-propyl)-9-((S)-4-hydroxy-benzyl)-12-((S)-isobutyl)-30-((S)-isopropyl)-8,11,14,17,23,29,32-heptaoxo-35-(S)-oxo-19lambda*4*-thia-7,10,13,16,22,28,31,34-octaaza-spiro[5.29]pentatriacontan-19-ol anion | CHEMBL408922
Type:
Small organic molecule
Emp. Form.:
C47H72N10O14S
Mol. Mass.:
1033.198
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](CCCC(O)=O)NC(=O)CS(=O)C[C@H](NC(=O)CCCCNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(C)C)C(N)=O
Structure:
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