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Target
Cathepsin K
Ligand
BDBM50137790
Substrate
n/a
Meas. Tech.
ChEBML_45556
IC50
51±n/a nM
Citation
 Boros, EE; Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Paulick, MG; Shewchuk, LM; Thompson, JB; Willard, DH; Wright, LL Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett 14:3425-9 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50137790
Synonyms:
((S)-1-Formyl-pentyl)-carbamic acid tert-butyl ester | (S)-tert-butyl 1-oxohexan-2-ylcarbamate | CHEMBL96875 | [(S)-1-(4-Bromo-1H-pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C11H21NO3
Mol. Mass.:
215.2893
SMILES:
CCCC[C@H](NC(=O)OC(C)(C)C)C=O
Structure:
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