Reaction Details
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Beta-3 adrenergic receptor
Ligand
BDBM50148504
Substrate
n/a
Meas. Tech.
ChEBML_39051
Ki
20±n/a nM
Citation
Washburn, WN; Sun, CQ; Bisacchi, G; Wu, G; Cheng, PT; Sher, PM; Ryono, D; Gavai, AV; Poss, K; Girotra, RN; McCann, PJ; Mikkilineni, AB; Dejneka, TC; Wang, TC; Merchant, Z; Morella, M; Arbeeny, CM; Harper, TW; Slusarchyk, DA; Skwish, S; Russell, AD; Allen, GT; Tesfamariam, B; Frohlich, BH; Abboa-Offei, BE; Cap, M; Waldron, TL; George, RJ; Young, D; Dickinson, KE; Seymour, AA BMS-201620: a selective beta 3 agonist. Bioorg Med Chem Lett 14:3525-9 (2004) [PubMed] Article More Info.:
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Inhibitor
Name:
BDBM50148504
Synonyms:
4-[(S)-2-[2-Hydroxy-2-((R)-4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-2-(4-methoxy-phenyl)-propionylamino]-N-propyl-benzamide | CHEMBL326820
Type:
Small organic molecule
Emp. Form.:
C29H36N4O7S
Mol. Mass.:
584.684
SMILES:
CCCNC(=O)c1ccc(NC(=O)[C@@](C)(NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c2ccc(OC)cc2)cc1
Structure:
