Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50149671
Substrate
n/a
Meas. Tech.
ChEMBL_302831 (CHEMBL838621)
Ki
1.2±n/a nM
Citation
 Huang, CQWilcoxen, KMGrigoriadis, DEMcCarthy, JRChen, C Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists. Bioorg Med Chem Lett 14:3943-7 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50149671
Synonyms:
CHEMBL362697 | [3-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C20H23ClF3N5
Mol. Mass.:
425.878
SMILES:
CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(3.94,6,;4.52,4.6,;3.59,3.37,;4.17,1.96,;5.71,1.73,;6.3,.3,;7.82,.11,;3.23,.72,;3.82,-.7,;2.88,-1.92,;3.47,-3.34,;1.36,-1.71,;.78,-.29,;-.67,.21,;-.63,1.77,;-1.85,2.7,;.85,2.19,;1.71,.91,;-2.07,-.47,;-2.07,-2.01,;-3.41,-2.78,;-4.74,-2.01,;-4.74,-.47,;-3.41,.3,;-3.41,1.85,;-6.08,-2.78,;-7.3,-3.47,;-7.59,-2.21,;-6.34,-4.37,)|
Structure:
Search PDB for entries with ligand similarity: