Target
Mitogen-activated protein kinase 14
Ligand
BDBM50153848
Substrate
n/a
Meas. Tech.
ChEMBL_305841 (CHEMBL829582)
IC50
10±n/a nM
Citation
 Brown, DSBelfield, AJBrown, GRCampbell, DFoubister, AMasters, DJPike, KGSnelson, WLWells, SL A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis. Bioorg Med Chem Lett 14:5383-7 (2004) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50153848
Synonyms:
CHEMBL184012 | N-{4-Methyl-3-[4-(pyridin-2-ylmethoxy)-benzoylamino]-phenyl}-2-morpholin-4-yl-isonicotinamide
Type:
Small organic molecule
Emp. Form.:
C30H29N5O4
Mol. Mass.:
523.5824
SMILES:
Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1
Structure:
Search PDB for entries with ligand similarity: