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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50153861
Substrate
n/a
Meas. Tech.
ChEMBL_305835 (CHEMBL874544)
IC50
10±n/a nM
Citation
 Cumming, JG; McKenzie, CL; Bowden, SG; Campbell, D; Masters, DJ; Breed, J; Jewsbury, PJ Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 14:5389-94 (2004) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50153861
Synonyms:
3-Fluoro-N-[4-methyl-3-(2-methylsulfanyl-pyrimidin-4-ylamino)-phenyl]-5-morpholin-4-yl-benzamide | CHEMBL187857
Type:
Small organic molecule
Emp. Form.:
C23H24FN5O2S
Mol. Mass.:
453.532
SMILES:
CSc1nccc(Nc2cc(NC(=O)c3cc(F)cc(c3)N3CCOCC3)ccc2C)n1
Structure:
Search PDB for entries with ligand similarity: