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Target
Cathepsin K
Ligand
BDBM50154158
Substrate
n/a
Meas. Tech.
ChEMBL_304938 (CHEMBL826967)
IC50
135±n/a nM
Citation
 Tavares, FX; Deaton, DN; Miller, AB; Miller, LR; Wright, LL; Zhou, HQ Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K. J Med Chem 47:5049-56 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50154158
Synonyms:
CHEMBL425535 | [1-(2-Methyl-2H-pyrazol-3-ylaminooxalyl)-pentyl]-carbamic acid 1-ethyl-cyclopentylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C20H32N4O4
Mol. Mass.:
392.4925
SMILES:
CCCC[C@H](NC(=O)OCC1(CC)CCCC1)C(=O)C(=O)Nc1ccnn1C
Structure:
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