Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50155463
Substrate
n/a
Meas. Tech.
ChEMBL_305768 (CHEMBL827105)
IC50
12680±n/a nM
Citation
 Moon, HR; Lee, HJ; Kim, KR; Lee, KM; Lee, SK; Kim, HO; Chun, MW; Jeong, LS Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase. Bioorg Med Chem Lett 14:5641-4 (2004) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50155463
Synonyms:
(1S,2R,5S)-3-Aminomethyl-5-(6-amino-purin-9-yl)-4-fluoro-cyclopent-3-ene-1,2-diol | CHEMBL187650
Type:
Small organic molecule
Emp. Form.:
C11H13FN6O2
Mol. Mass.:
280.2583
SMILES:
NCC1=C(F)[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |c:2|
Structure:
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