Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50077537
Substrate
n/a
Meas. Tech.
ChEMBL_303031 (CHEMBL830418)
Ki
47±n/a nM
Citation
 Grunewald, GL; Romero, FA; Seim, MR; Criscione, KR; Deupree, JD; Spackman, CC; Bylund, DB Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Bioorg Med Chem Lett 15:1143-7 (2005) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50077537
Synonyms:
(+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol | (7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol | CHEMBL59441
Type:
Small organic molecule
Emp. Form.:
C10H12N2O3
Mol. Mass.:
208.2139
SMILES:
OCC1Cc2ccc(cc2CN1)[N+]([O-])=O
Structure:
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