Reaction Details Report a problem with these data
Target
D(1B) dopamine receptor
Ligand
BDBM50166032
Substrate
n/a
Meas. Tech.
ChEMBL_302994 (CHEMBL830233)
Ki
>50000±n/a nM
Citation
 Ding, K; Chen, J; Ji, M; Wu, X; Varady, J; Yang, CY; Lu, Y; Deschamps, JR; Levant, B; Wang, S Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands. J Med Chem 48:3171-81 (2005) [PubMed]  Article 
Target
Name:
D(1B) dopamine receptor
Synonyms:
D(1B) dopamine receptor | DOPAMINE D5 | DRD5_RAT | Dopamine D1B | Dopamine D5 receptor | Dopamine receptor | Drd5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52827.88
Organism:
RAT
Description:
Dopamine D1B 0 RAT::P25115
Residue:
475
Sequence:
MLPPGRNRTAQPARLGLQRQLAQVDAPAGSATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGTFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGAYEPDPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHFCFRTPVQTVNISNELISYNQDTVFHKEIATAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFDKTA
  
Inhibitor
Name:
BDBM50166032
Synonyms:
CHEMBL191894 | Naphthalene-2-carboxylic acid {4-[2-((S)-8-methoxy-1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinolin-3-yl)-ethyl]-cyclohexyl}-amide
Type:
Small organic molecule
Emp. Form.:
C32H39N3O2
Mol. Mass.:
497.671
SMILES:
COc1ccc2N3CCN(CCC4CCC(CC4)NC(=O)c4ccc5ccccc5c4)C[C@@H]3CCc2c1 |wU:32.35,(-5.22,2.89,;-3.9,3.66,;-2.54,2.93,;-2.52,1.37,;-1.19,.65,;.12,1.42,;1.48,.67,;1.42,-.85,;2.75,-1.66,;4.11,-.89,;5.65,-.87,;6.45,-2.2,;7.99,-2.18,;8.73,-.84,;10.27,-.82,;11.06,-2.15,;10.3,-3.48,;8.77,-3.51,;12.6,-2.13,;13.35,-.78,;12.56,.55,;14.89,-.77,;15.63,.58,;17.17,.61,;17.95,-.71,;19.47,-.68,;20.26,-1.98,;19.54,-3.32,;18,-3.36,;17.2,-2.06,;15.66,-2.08,;4.13,.67,;2.8,1.46,;2.78,3,;1.43,3.75,;.12,2.96,;-1.23,3.7,)|
Structure:
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