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Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM50166488
Substrate
n/a
Meas. Tech.
ChEMBL_304763 (CHEMBL829360)
IC50
>50000±n/a nM
Citation
 Kutterer, KM; Davis, JM; Singh, G; Yang, Y; Hu, W; Severin, A; Rasmussen, BA; Krishnamurthy, G; Failli, A; Katz, AH 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett 15:2527-31 (2005) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ
Type:
Protein
Mol. Mass.:
44814.62
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
E. coli MurA
Residue:
419
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
  
Inhibitor
Name:
BDBM50166488
Synonyms:
4-(2-Benzyloxy-ethyl)-1,2-bis-(4-chloro-phenyl)-4-methyl-pyrazolidine-3,5-dione | CHEMBL191952
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2N2O3
Mol. Mass.:
469.36
SMILES:
CC1(CCOCc2ccccc2)C(=O)N(N(C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
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