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Target
Methionine aminopeptidase 1
Ligand
BDBM50129648
Substrate
n/a
Meas. Tech.
ChEMBL_311942 (CHEMBL833409)
IC50
140000±n/a nM
Citation
 Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives. Bioorg Med Chem Lett 15:3732-6 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1
Type:
PROTEIN
Mol. Mass.:
43382.92
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_10701
Residue:
387
Sequence:
MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYKAHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQRNDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYPSPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGENISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFFHCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHTLLVTEHGVEILTARNKKSPGGPRQRIK
  
Inhibitor
Name:
BDBM50129648
Synonyms:
3-(4-Methyl-pent-3-enoylamino)-pyridine-2-carboxylic acid thiazol-2-ylamide | CHEMBL328350
Type:
Small organic molecule
Emp. Form.:
C15H16N4O2S
Mol. Mass.:
316.378
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6](=O)-[#7]-c1cccnc1-[#6](=O)-[#7]-c1nccs1
Structure:
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