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Target
RNA-directed RNA polymerase
Ligand
BDBM50169927
Substrate
n/a
Meas. Tech.
ChEMBL_305448 (CHEMBL830123)
IC50
31±n/a nM
Citation
Harper, S; Avolio, S; Pacini, B; Di Filippo, M; Altamura, S; Tomei, L; Paonessa, G; Di Marco, S; Carfi, A; Giuliano, C; Padron, J; Bonelli, F; Migliaccio, G; De Francesco, R; Laufer, R; Rowley, M; Narjes, F Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase. J Med Chem 48:4547-57 (2005) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50169927
Synonyms:
3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-furan-3-yl-1H-indole-6-carboxylic acid | 3-cyclohexyl-1-(2-(dimethylamino)-2-oxoethyl)-2-(furan-3-yl)-1H-indole-6-carboxylic acid | CHEMBL190558
Type:
Small organic molecule
Emp. Form.:
C23H26N2O4
Mol. Mass.:
394.4635
SMILES:
CN(C)C(=O)Cn1c(-c2ccoc2)c(C2CCCCC2)c2ccc(cc12)C(O)=O