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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM13023
Substrate
n/a
Meas. Tech.
ChEMBL_326878 (CHEMBL862979)
Ki
52±n/a nM
Citation
 Grunewald, GL; Lu, J; Criscione, KR; Okoro, CO Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. Bioorg Med Chem Lett 15:5319-23 (2005) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM13023
Synonyms:
3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | 7-sulfonamide-THIQ 13 | CHEMBL41647
Type:
Small organic molecule
Emp. Form.:
C10H14N2O3S
Mol. Mass.:
242.295
SMILES:
NS(=O)(=O)c1ccc2CC(CO)NCc2c1
Structure:
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