Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50174831
Substrate
n/a
Meas. Tech.
ChEMBL_326855 (CHEMBL860452)
Ki
>3000±n/a nM
Citation
Palani, A; Shapiro, S; McBriar, MD; Clader, JW; Greenlee, WJ; O'Neill, K; Hawes, B Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 15:5234-6 (2005) [PubMed] Article
More Info.:
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
Inhibitor
Name:
BDBM50174831
Synonyms:
CHEMBL196864 | N-(3'-cyano-biphenyl-4-ylmethyl)-N-[(3,5-dichloro-phenylcarbamoyl)-methyl]-2-((S)-3-hydroxy-pyrrolidin-1-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C28H26Cl2N4O3
Mol. Mass.:
537.437
SMILES:
O[C@H]1CCN(CC(=O)N(CC(=O)Nc2cc(Cl)cc(Cl)c2)Cc2ccc(cc2)-c2cccc(c2)C#N)C1