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Target
Delta-type opioid receptor
Ligand
BDBM50175726
Substrate
n/a
Meas. Tech.
ChEMBL_328876 (CHEMBL859855)
Ki
>465±n/a nM
Citation
 Trabanco, AA; Pullan, S; Alonso, JM; Alvarez, RM; Andrés, JI; Boeckx, I; Fernández, J; Gómez, A; Iturrino, L; Janssens, FE; Leenaerts, JE; De Lucas, AI; Matesanz, E; Meert, T; Steckler, T 4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists. Bioorg Med Chem Lett 16:146-9 (2005) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50175726
Synonyms:
4-(1H-imidazol-2-yl)-N,4-diphenylpiperidine-1-carboxamide | CHEMBL199738
Type:
Small organic molecule
Emp. Form.:
C21H22N4O
Mol. Mass.:
346.4256
SMILES:
O=C(Nc1ccccc1)N1CCC(CC1)(c1ncc[nH]1)c1ccccc1
Structure:
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