Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50176252
Substrate
n/a
Meas. Tech.
ChEMBL_334349 (CHEMBL862208)
Ki
1±n/a nM
Citation
 Young, WB; Sprengeler, P; Shrader, WD; Li, Y; Rai, R; Verner, E; Jenkins, T; Fatheree, P; Kolesnikov, A; Janc, JW; Cregar, L; Elrod, K; Katz, B Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation. Bioorg Med Chem Lett 16:710-3 (2005) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50176252
Synonyms:
2-((6-fluoro-1H-benzo[d]imidazol-2-yl)methyl)-1H-benzo[d]imidazole-5-carboxamidine | CHEMBL377077
Type:
Small organic molecule
Emp. Form.:
C16H13FN6
Mol. Mass.:
308.313
SMILES:
NC(=N)c1ccc2nc(Cc3nc4ccc(F)cc4[nH]3)[nH]c2c1
Structure:
Search PDB for entries with ligand similarity: