Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50176447
Substrate
n/a
Meas. Tech.
ChEMBL_332996 (CHEMBL853593)
Ki
9.2±n/a nM
Citation
Geneste, H; Backfisch, G; Braje, W; Delzer, J; Haupt, A; Hutchins, CW; King, LL; Lubisch, W; Steiner, G; Teschendorf, HJ; Unger, L; Wernet, W Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com. Bioorg Med Chem Lett 16:658-62 (2005) [PubMed] Article
More Info.:
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
Inhibitor
Name:
BDBM50176447
Synonyms:
1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)but-2-enyl)-3,4-dihydroquinolin-2(1H)-one | CHEMBL201557
Type:
Small organic molecule
Emp. Form.:
C26H32F3N5O
Mol. Mass.:
487.5604
SMILES:
CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(C\C=C\CN2C(=O)CCc3ccccc23)CC1