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Target
D(3) dopamine receptor
Ligand
BDBM50177362
Substrate
n/a
Meas. Tech.
ChEMBL_329734 (CHEMBL864615)
Ki
5.1±n/a nM
Citation
 Chen, J; Ding, K; Levant, B; Wang, S Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorg Med Chem Lett 16:443-6 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50177362
Synonyms:
CHEMBL201339 | N-(trans-4-(2-(8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethyl)cyclohexyl)-2-naphthamide
Type:
Small organic molecule
Emp. Form.:
C32H39N3O2
Mol. Mass.:
497.671
SMILES:
COc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4ccc5ccccc5c4)CC3CCc2c1 |wU:15.18,wD:12.11,(15.98,1.32,;17.31,2.09,;18.64,1.31,;18.64,-.24,;19.97,-1.01,;21.31,-.24,;22.66,-1.02,;22.67,-2.56,;24.02,-3.34,;25.36,-2.55,;26.7,-3.31,;28.03,-2.53,;29.37,-3.29,;29.37,-4.83,;30.7,-5.6,;32.03,-4.82,;32.02,-3.28,;30.68,-2.51,;33.36,-5.59,;33.37,-7.13,;34.7,-7.9,;32.04,-7.9,;32.04,-9.44,;30.72,-10.21,;29.37,-9.44,;28.05,-10.21,;26.72,-9.45,;26.72,-7.91,;28.05,-7.14,;29.38,-7.91,;30.7,-7.13,;25.35,-.99,;24,-.23,;23.99,1.33,;22.64,2.1,;21.31,1.32,;19.97,2.08,)|
Structure:
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