Target
D(3) dopamine receptor
Ligand
BDBM50177365
Substrate
n/a
Meas. Tech.
ChEMBL_329734 (CHEMBL864615)
Ki
87±n/a nM
Citation
 Chen, JDing, KLevant, BWang, S Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorg Med Chem Lett 16:443-6 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50177365
Synonyms:
CHEMBL264520 | N-(trans-4-(2-(8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethyl)cyclohexyl)quinoline-8-carboxamide
Type:
Small organic molecule
Emp. Form.:
C31H38N4O2
Mol. Mass.:
498.659
SMILES:
COc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4cccc5cccnc45)CC3CCc2c1 |wU:15.18,wD:12.11,(-10.09,-16.28,;-8.76,-15.51,;-7.43,-16.29,;-7.43,-17.83,;-6.1,-18.6,;-4.75,-17.84,;-3.41,-18.61,;-3.4,-20.16,;-2.05,-20.93,;-.71,-20.15,;.63,-20.91,;1.96,-20.13,;3.3,-20.89,;3.3,-22.43,;4.63,-23.19,;5.96,-22.42,;5.96,-20.88,;4.62,-20.11,;7.3,-23.19,;7.3,-24.73,;8.63,-25.49,;5.97,-25.5,;4.63,-24.73,;3.3,-25.5,;3.31,-27.04,;4.65,-27.8,;4.66,-29.33,;5.99,-30.09,;7.31,-29.31,;7.3,-27.78,;5.97,-27.03,;-.71,-18.59,;-2.07,-17.83,;-2.07,-16.27,;-3.43,-15.49,;-4.76,-16.28,;-6.1,-15.52,)|
Structure:
Search PDB for entries with ligand similarity: