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TargetDopamine receptor
LigandBDBM50177364
Substrate/Competitorn/a
Meas. Tech.ChEMBL_329734
Ki 183±n/a nM
Citation Chen, JDing, KLevant, BWang, S Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorg Med Chem Lett16:443-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine receptor
Name:Dopamine receptor D2 and D3
Synonyms:D(3) dopamine receptor | DOPAMINE D3 | DRD3 | Dopamine D3 receptor
Type:Protein
Mol. Mass.:49540.58
Organism:Rattus norvegicus (Rat)
Description:P19020
Residue:446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
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  Blast E-value cutoff:
BDBM50177364
NameBDBM50177364
Synonyms:CHEMBL200183 | N-(trans-4-(2-(8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethyl)cyclohexyl)quinoline-2-carboxamide
TypeSmall organic molecule
Emp. Form.C31H38N4O2
Mol. Mass.498.659
SMILESCOc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4ccc5ccccc5n4)CC3CCc2c1 |wU:15.18,wD:12.11,(-8.46,-38.9,;-7.12,-38.13,;-5.79,-38.91,;-5.79,-40.45,;-4.46,-41.22,;-3.12,-40.46,;-1.78,-41.23,;-1.77,-42.78,;-.42,-43.55,;.93,-42.77,;2.26,-43.53,;3.59,-42.75,;4.93,-43.51,;4.93,-45.05,;6.26,-45.81,;7.59,-45.04,;7.59,-43.5,;6.25,-42.73,;8.93,-45.81,;8.93,-47.35,;10.27,-48.12,;7.6,-48.12,;7.61,-49.65,;6.28,-50.43,;4.94,-49.66,;3.62,-50.43,;2.29,-49.67,;2.29,-48.12,;3.62,-47.36,;4.94,-48.13,;6.27,-47.35,;.92,-41.21,;-.43,-40.45,;-.44,-38.89,;-1.79,-38.11,;-3.13,-38.9,;-4.47,-38.14,)|
Structure
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