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Target
D(3) dopamine receptor
Ligand
BDBM50177367
Substrate
n/a
Meas. Tech.
ChEMBL_329734 (CHEMBL864615)
Ki
48±n/a nM
Citation
 Chen, J; Ding, K; Levant, B; Wang, S Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorg Med Chem Lett 16:443-6 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50177367
Synonyms:
CHEMBL201702 | N-(trans-4-(2-(8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethyl)cyclohexyl)isoquinoline-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C31H38N4O2
Mol. Mass.:
498.659
SMILES:
COc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4cc5ccccc5cn4)CC3CCc2c1 |wU:15.18,wD:12.11,(-9.33,-16.65,;-8,-15.88,;-6.66,-16.66,;-6.67,-18.2,;-5.34,-18.97,;-3.99,-18.21,;-2.65,-18.98,;-2.64,-20.53,;-1.29,-21.3,;.06,-20.51,;1.39,-21.27,;2.72,-20.5,;4.06,-21.26,;4.06,-22.8,;5.39,-23.56,;6.72,-22.79,;6.72,-21.25,;5.38,-20.48,;8.06,-23.56,;8.06,-25.1,;9.39,-25.86,;6.73,-25.87,;5.39,-25.1,;4.07,-25.87,;2.74,-25.1,;1.41,-25.87,;1.42,-27.41,;2.74,-28.17,;4.07,-27.41,;5.41,-28.18,;6.74,-27.4,;.05,-18.95,;-1.31,-18.19,;-1.31,-16.64,;-2.66,-15.86,;-4,-16.65,;-5.34,-15.89,)|
Structure:
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