Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50177898
Substrate
n/a
Meas. Tech.
ChEMBL_325740 (CHEMBL864530)
Ki
0.13±n/a nM
Citation
 Henriksen, G; Platzer, S; Marton, J; Hauser, A; Berthele, A; Schwaiger, M; Marinelli, L; Lavecchia, A; Novellino, E; Wester, HJ Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents. J Med Chem 48:7720-32 (2005) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50177898
Synonyms:
2-Fluoro-N-[4-methoxymethyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-N-phenyl-propionamide | CHEMBL196960 | N-[1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenyl-2-[(+/-)-[18F]fluoropropanamide
Type:
Small organic molecule
Emp. Form.:
C22H29FN2O2S
Mol. Mass.:
404.541
SMILES:
COCC1(CCN(CCc2cccs2)CC1)N(C(=O)C(C)F)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: