Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50178620
Substrate
n/a
Meas. Tech.
ChEMBL_325303 (CHEMBL859710)
Ki
22.8±n/a nM
Citation
 Leopoldo, M; Lacivita, E; Colabufo, NA; Contino, M; Berardi, F; Perrone, R First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure. J Med Chem 48:7919-22 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50178620
Synonyms:
CHEMBL361228 | trans-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-phenylcyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C27H35Cl2N3O
Mol. Mass.:
488.492
SMILES:
Clc1cccc(N2CCN(CCCCNC(=O)[C@H]3CC[C@@H](CC3)c3ccccc3)CC2)c1Cl |wU:17.16,wD:20.23,(10.81,-29.1,;9.48,-28.31,;9.5,-26.77,;8.17,-25.99,;6.83,-26.74,;6.82,-28.28,;5.48,-29.03,;5.46,-30.57,;4.12,-31.32,;2.81,-30.54,;1.47,-31.29,;1.45,-32.83,;.11,-33.61,;-1.22,-32.84,;-1.22,-31.3,;-2.56,-30.53,;-2.56,-28.99,;-3.89,-31.3,;-3.89,-32.84,;-5.23,-33.6,;-6.56,-32.83,;-6.55,-31.29,;-5.22,-30.52,;-7.9,-33.59,;-9.23,-32.81,;-10.56,-33.58,;-10.57,-35.12,;-9.23,-35.89,;-7.9,-35.13,;2.8,-29,;4.15,-28.24,;8.14,-29.07,;8.12,-30.61,)|
Structure:
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