Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50178769
Substrate
n/a
Meas. Tech.
ChEMBL_325280 (CHEMBL859691)
IC50
48700±n/a nM
Citation
 Napper, ADHixon, JMcDonagh, TKeavey, KPons, JFBarker, JYau, WTAmouzegh, PFlegg, AHamelin, EThomas, RJKates, MJones, SNavia, MASaunders, JODiStefano, PSCurtis, R Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem 48:8045-54 (2005) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50178769
Synonyms:
(+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CHEMBL420311
Type:
Small organic molecule
Emp. Form.:
C13H13ClN2O
Mol. Mass.:
248.708
SMILES:
NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Structure:
Search PDB for entries with ligand similarity: