Target

Ligand

Substrate

Meas. Tech.

ChEMBL_325280 (CHEMBL859691)

Citation

 Napper, AD; Hixon, J; McDonagh, T; Keavey, K; Pons, JF; Barker, J; Yau, WT; Amouzegh, P; Flegg, A; Hamelin, E; Thomas, RJ; Kates, M; Jones, S; Navia, MA; Saunders, JO; DiStefano, PS; Curtis, R Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem 48:8045-54 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Synonyms:

NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3

Type:

Protein

Mol. Mass.:

43582.69

Organism:

Homo sapiens (Human)

Description:

Q9NTG7

Residue:

399

Sequence:

MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK

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Name:

BDBM50178766

Synonyms:

2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide | 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide | CHEMBL446446

Type:

Small organic molecule

Emp. Form.:

C14H15ClN2O

Mol. Mass.:

262.735

SMILES:

NC(=O)C1CCCCc2c1[nH]c1ccc(Cl)cc21

Structure:

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