Reaction Details Report a problem with these data
Target
Fibroblast growth factor 1
Ligand
BDBM50179256
Substrate
n/a
Meas. Tech.
ChEMBL_325518 (CHEMBL860173)
Kd
0.390±n/a nM
Citation
 Karoli, T; Liu, L; Fairweather, JK; Hammond, E; Li, CP; Cochran, S; Bergefall, K; Trybala, E; Addison, RS; Ferro, V Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88). J Med Chem 48:8229-36 (2005) [PubMed]  Article 
Target
Name:
Fibroblast growth factor 1
Synonyms:
Acidic fibroblast growth factor | Beta-endothelial cell growth factor | ECGF-beta | FGF1 | FGF1_HUMAN | FGFA | Fibroblast growth factor 1 (FGF-1) | HBGF-1 | Heparin-binding growth factor 1 | aFGF
Type:
Protein
Mol. Mass.:
17461.01
Organism:
Homo sapiens (Human)
Description:
P05230
Residue:
155
Sequence:
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
  
Inhibitor
Name:
BDBM50179256
Synonyms:
6-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-N-[(2S,3S,4S,5S,6R)-3-{[(2R,3S,4S,5R,6R)-4-{[(2R,3S,4S,5R,6R)-4-{[(2R,3S,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]hexanamide | CHEMBL262707
Type:
Small organic molecule
Emp. Form.:
C46H78N4O28S
Mol. Mass.:
1167.187
SMILES:
OC[C@H]1O[C@H](NC(=O)CCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H](O)[C@@H]1O
Structure:
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