Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50179876
Substrate
n/a
Meas. Tech.
ChEMBL_340909 (CHEMBL860635)
EC50
100±n/a nM
Citation
 Li, LLiu, JZhu, LCutler, SHasegawa, HShan, BMedina, JC Discovery and optimization of a novel series of liver X receptor-alpha agonists. Bioorg Med Chem Lett 16:1638-42 (2006) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50179876
Synonyms:
1,1,1,3,3,3-hexafluoro-2-(4-(phenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)propan-2-ol | CHEMBL381570
Type:
Small organic molecule
Emp. Form.:
C17H13F6NO4S
Mol. Mass.:
441.345
SMILES:
OC(c1ccc2N(CCOc2c1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: