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Target
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
Ligand
BDBM50180778
Substrate
n/a
Meas. Tech.
ChEMBL_327201 (CHEMBL859562)
Ki
0.006000±n/a nM
Citation
 Lang, M; De Pol, S; Baldauf, C; Hofmann, HJ; Reiser, O; Beck-Sickinger, AG Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem 49:616-24 (2006) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1
Synonyms:
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 327200
Components:
This complex has 2 components.
Component 1
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52980.45
Organism:
Homo sapiens (Human)
Description:
Q16602
Residue:
461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
  
Component 2
Name:
Receptor activity-modifying protein 1
Synonyms:
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
16992.80
Organism:
Homo sapiens (Human)
Description:
EBI_100673
Residue:
148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
  
Inhibitor
Name:
BDBM50180778
Synonyms:
CHEMBL2371891 | FV-Hyp-TDVGPFAF
Type:
Small organic molecule
Emp. Form.:
C60H81N11O16
Mol. Mass.:
1212.3492
SMILES:
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Structure:
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