Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50181177
Substrate
n/a
Meas. Tech.
ChEMBL_345662 (CHEMBL870659)
IC50
19±n/a nM
Citation
 Liu, BLiu, MXin, ZZhao, HSerby, MDKosogof, CNelson, LTSzczepankiewicz, BGKaszubska, WSchaefer, VGFalls, HDLin, CWCollins, CASham, HLLiu, G Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration. Bioorg Med Chem Lett 16:1864-8 (2006) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50181177
Synonyms:
5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-pentylpyrimidine-2,4-diamine | CHEMBL206687
Type:
Small organic molecule
Emp. Form.:
C23H29N5O2S
Mol. Mass.:
439.574
SMILES:
CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: