Target
RNA-directed RNA polymerase
Ligand
BDBM50181567
Substrate
n/a
Meas. Tech.
ChEMBL_330651 (CHEMBL867029)
IC50
34±n/a nM
Citation
 Tedesco, RShaw, ANBambal, RChai, DConcha, NODarcy, MGDhanak, DFitch, DMGates, AGerhardt, WGHalegoua, DLHan, CHofmann, GAJohnston, VKKaura, ACLiu, NKeenan, RMLin-Goerke, JSarisky, RTWiggall, KJZimmerman, MNDuffy, KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem 49:971-83 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50181567
Synonyms:
4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydroquinolin-6-yloxy]acetonitrile | CHEMBL201690
Type:
Small organic molecule
Emp. Form.:
C23H22N4O5S
Mol. Mass.:
466.51
SMILES:
CC(C)CCn1c2ccc(OCC#N)cc2c(O)c(C2=Nc3ccccc3S(=O)(=O)N2)c1=O |t:20|
Structure:
Search PDB for entries with ligand similarity: