Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50181735
Substrate
n/a
Meas. Tech.
ChEMBL_331786 (CHEMBL864669)
IC50
100±n/a nM
Citation
Powers, JP; Piper, DE; Li, Y; Mayorga, V; Anzola, J; Chen, JM; Jaen, JC; Lee, G; Liu, J; Peterson, MG; Tonn, GR; Ye, Q; Walker, NP; Wang, Z SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase. J Med Chem 49:1034-46 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50181735
Synonyms:
5-(5-[2-chloro-5-(trifluoromethyl)phenyl]-furan-2-methylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | CHEMBL381101
Type:
Small organic molecule
Emp. Form.:
C21H12ClF3N2O4S3
Mol. Mass.:
544.974
SMILES:
FC(F)(F)c1ccc(Cl)c(c1)-c1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)o1 |w:15.15|