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Target
RNA-directed RNA polymerase
Ligand
BDBM50181689
Substrate
n/a
Meas. Tech.
ChEMBL_331786 (CHEMBL864669)
IC50
3000±n/a nM
Citation
 Powers, JP; Piper, DE; Li, Y; Mayorga, V; Anzola, J; Chen, JM; Jaen, JC; Lee, G; Liu, J; Peterson, MG; Tonn, GR; Ye, Q; Walker, NP; Wang, Z SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase. J Med Chem 49:1034-46 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50181689
Synonyms:
5-(2,4-difluorobenzylidene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | CHEMBL200986
Type:
Small organic molecule
Emp. Form.:
C16H10F2N2O3S3
Mol. Mass.:
412.454
SMILES:
Fc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)c(F)c1 |w:5.4|
Structure:
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