Target
Coagulation factor VII/Tissue factor
Ligand
BDBM50181921
Substrate
n/a
Meas. Tech.
ChEMBL_347650 (CHEMBL870677)
Ki
1±n/a nM
Citation
 Kolesnikov, ARai, RYoung, WBMordenti, JLiu, LTorkelson, SShrader, WDLeahy, EMHu, HGjerstad, EJanc, JKatz, BASprengeler, PA Factor VIIa inhibitors: improved pharmacokinetic parameters. Bioorg Med Chem Lett 16:2243-6 (2006) [PubMed]  Article 
Target
Name:
Coagulation factor VII/Tissue factor
Synonyms:
Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 69535
Components:
This complex has 2 components.
Component 1
Name:
Tissue factor
Synonyms:
CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor
Type:
PROTEIN
Mol. Mass.:
33067.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_936735
Residue:
295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
  
Component 2
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50181921
Synonyms:
2-[5-(5-carbamimidoyl-1H-indol-2-yl)-6-hydroxy-3'-nitro-biphenyl-3-yl]-succinic acid | CHEMBL382879
Type:
Small organic molecule
Emp. Form.:
C25H20N4O7
Mol. Mass.:
488.4489
SMILES:
NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(cc(c1O)-c1cccc(c1)[N+]([O-])=O)C(CC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: