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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50182886
Substrate
n/a
Meas. Tech.
ChEMBL_351034 (CHEMBL866259)
IC50
5840±n/a nM
Citation
 Beevers, RE; Buckley, GM; Davies, N; Fraser, JL; Galvin, FC; Hannah, DR; Haughan, AF; Jenkins, K; Mack, SR; Pitt, WR; Ratcliffe, AJ; Richard, MD; Sabin, V; Sharpe, A; Williams, SC Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett 16:2535-8 (2006) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50182886
Synonyms:
3-(furan-3-yl)-1H-indole | CHEMBL381132
Type:
Small organic molecule
Emp. Form.:
C12H9NO
Mol. Mass.:
183.206
SMILES:
c1cc(co1)-c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: