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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50182928
Substrate
n/a
Meas. Tech.
ChEMBL_351089 (CHEMBL866272)
IC50
7680±n/a nM
Citation
 Beevers, RE; Buckley, GM; Davies, N; Fraser, JL; Galvin, FC; Hannah, DR; Haughan, AF; Jenkins, K; Mack, SR; Pitt, WR; Ratcliffe, AJ; Richard, MD; Sabin, V; Sharpe, A; Williams, SC Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett 16:2539-42 (2006) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50182928
Synonyms:
CHEMBL205236 | N-(3-cyano-1-methyl-1H-indol-6-yl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C16H13N3O2S
Mol. Mass.:
311.358
SMILES:
Cn1cc(C#N)c2ccc(NS(=O)(=O)c3ccccc3)cc12
Structure:
Search PDB for entries with ligand similarity: