Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50183219
Substrate
n/a
Meas. Tech.
ChEMBL_354582 (CHEMBL865109)
EC50
950±n/a nM
Citation
 McKerrecher, D; Allen, JV; Caulkett, PW; Donald, CS; Fenwick, ML; Grange, E; Johnson, KM; Johnstone, C; Jones, CD; Pike, KG; Rayner, JW; Walker, RP Design of a potent, soluble glucokinase activator with excellent in vivo efficacy. Bioorg Med Chem Lett 16:2705-9 (2006) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50183219
Synonyms:
(R)-6-(3-isopropoxy-5-(1-phenylethoxy)benzamido)nicotinic acid | CHEMBL208197
Type:
Small organic molecule
Emp. Form.:
C24H24N2O5
Mol. Mass.:
420.4578
SMILES:
CC(C)Oc1cc(O[C@H](C)c2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: