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Target
RNA-directed RNA polymerase
Ligand
BDBM50183486
Substrate
n/a
Meas. Tech.
ChEMBL_337076 (CHEMBL864354)
IC50
760±n/a nM
Citation
 Koch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49:1693-705 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50183486
Synonyms:
5,6-dihydroxy-2-(1,3-thiazol-2-yl)pyrimidine-4-carboxylic Acid | CHEMBL382383
Type:
Small organic molecule
Emp. Form.:
C8H5N3O4S
Mol. Mass.:
239.208
SMILES:
OC(=O)c1nc([nH]c(=O)c1O)-c1nccs1
Structure:
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