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Target
RNA-directed RNA polymerase
Ligand
BDBM50153254
Substrate
n/a
Meas. Tech.
ChEMBL_337085 (CHEMBL854142)
IC50
4200±n/a nM
Citation
Koch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49:1693-705 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50153254
Synonyms:
5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid | 5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid | CHEMBL366051
Type:
Small organic molecule
Emp. Form.:
C10H8N2O4S
Mol. Mass.:
252.247
SMILES:
Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccs1