Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50183498
Substrate
n/a
Meas. Tech.
ChEMBL_337076 (CHEMBL864354)
IC50
280±n/a nM
Citation
Koch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49:1693-705 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50183498
Synonyms:
5,6-dihydroxy-2-(3-{[(2-phenyl-1H-indol-3-yl)acetyl]amino}-2-thienyl)pyrimidine-4-carboxylic acid | CHEMBL205118
Type:
Small organic molecule
Emp. Form.:
C25H18N4O5S
Mol. Mass.:
486.499
SMILES:
OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)Cc1c([nH]c2ccccc12)-c1ccccc1